AOD9604 (Frag 176-191)



AOD9604 is an anti-obesity peptide based on human growth hormone.

AOD9604 is a peptide (a chain of amino acids). AOD stands for “Anti Obesity Drug”. This peptide has an amino acid sequence that mimics the lipolytic region of human growth hormone (the region of this hormone thought to be responsible for burning fat) and it has been promoted variously as a weight loss supplement, as an aid to muscle and cartilage repair, and a treatment for osteoarthritis. It is also known as lipotropin and Tyr-hGH fragment.

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What Is AOD9604

Basically, AOD-9604 is the code name for a drug that has advanced through stage II trials as a treatment for obesity. While there are quite a few similar drugs currently in research and trial phases, this one is showing some very positive signs.

Human Growth Hormone (hGH) is one of the most influential hormones in the body when it comes to the breakdown of fatty tissue. AOD9604 was designed as a partial peptide to mimic only a part of the function of hGH.

In this manner it works very similar to SARMs in that it is a highly targeted treatment resulting in fewer side effects both in the short and long-term.


How Does AOD-9604 Work?

Unlike traditional hGH treatment, AOD-9604 provides a very targeted effect. Because it only contains the binding effect for receptors that trigger the breakdown of stored body fat (lipolysis) it doesn’t come with a large number of knock on effects.

Unlike anabolic steroids, this product has far less impact on the build-up of muscle and bone tissue. Those anabolic effects are often linked to other severe side effects on the liver and prostate.

While the benefits of this drug are not as wide ranging as with many popular SARMs, this does provide a highly targeted approach ideal for exploration with other drugs.


What are the Benefits of AOD?

AOD 9604 drug was specifically designed and tested for the purpose of treating obesity through impacts on the metabolic rate even in resting stages. Those effects also come with some additional beneficial impacts that need to be understood in order to further develop the treatment process.

These benefits also provide insights into the use of the drug in many other areas for treatment of different types of diseases.
Here are the main recorded benefits:

  1. – Body Fat Reduction
    Unlike anabolic drugs that boost the production of Insulin like Growth Factor (IGF1) this drug targets only the metabolic processes that break down stored fat and release it in the form of energy (s. 1, 3).
  2. – More Defined Muscles
    This should not be mistaken for an actual boost in muscle mass. The definition of muscle shape improves due to the reduction of stored fat underneath the skin, which can also contain increased fluid. (s. 1).
  3. – Boosts Energy Levels
    The breakdown of fat releases significant amounts of energy increasing stamina and strength (s. 2).


What are the Side Effects of 9604?

Even with the very targeted effect, there have been some side effects noted in clinical trials. These are the main reason that the drug was not recommended for long-term testing, and further trials would be required to better understand them.

However, the side effects were few and limited to these impacts reported during the trial phases:

  1. – Headaches
    Several test subjects reported an increased frequency of headaches shortly after having the drug applied (s. 1).
  2. – Elated Mood Swings
    A few test subjects reported some euphoric like effects immediately after taking the drug (s. 1).


Cited studies:


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